Genotyping Applications

c.ATG offers whole genotyping analysis of highest quality. We provide our customers with complete solutions for their genotyping experiment from initial consulting in experiment design to in-depth bioinformatics analysis and interpretation. You can rely on our experience, with hundreds of studies conducted for customers in industry and academia.

Our clients conduct genome-wide association studies, chromosome copy number studies, linkage analyses, and population genetic studies. They generally interrogate 50,000 - 1 million single-nucleotide polymorphisms (SNPs) per sample. For these applications we offer a complete genotyping solution.

CytoScan HD Array

The CytoScan HD array was developed for reliable detection of chromosomal aberrations based on the Genome-Wide Human SNP Array 6.0. It contains more than 2.6 million markers for copy number analysis and approximately 750,000 SNPs that fully genotype with greater than 99 percent accuracy. It is suitable for high resolution copy number analysis (CN), accurate breakpoint estimation, detection of loss of heterozygosity (LOH), detection of uniparental disomy (UPD), detection of mosaicism (>15 %), linkage analysis and association studies.

CytoScan 750K Array

The CytoScan 750K Array was developed to provide a cost-effective solution that delivers industry-leading performance. It contains probes empirically selected from the CytoScan HD Array for more than 750,000 markers for copy number analysis, consisting of 550,000 unique non-polymorphic probes and approximately 200,000 SNPs that fully genotype with greater than 99 %accuracy.

CytoScan Optima Array

The CytoScan Optima Array was developed for robust and streamlined analysis of prenatal and miscarriage samples. The array content has been empirically selected from the CytoScan HD Array and consists of a total of 315,608 features covering control, copy number (CN), and single-nucleotide polymorphism (SNP) probes. There is a total of 18,018 CN and 148,450 SNP markers uniformly spaced over the genome with increased resolution in 396 regions of prenatal interest.

OncoScan Array

The OncoScan Array was developed for cancer applications. The OncoScan assay utilizes the Molecular Inversion Probe (MIP) technology, which has been optimized for highly degraded FFPE samples. It enables whole-genome copy number (CN), loss of heterozygosity (LOH), and key somatic mutations analysis and provides high-resolution copy number detection (50-100 kb copy number resolution in ~900 cancer genes, 300 kb genome-wide copy number resolution outside of the cancer genes).

Array

Marker

Requested input

Specification

CytoScan HD

2.6 Mio CN marker, 750,000 SNP marker

250 ng DNA

Exceeds cytogenetics community guidelines for specificity, sensitivity, and resolution across the genome

CytoScan 750K

550,000 CN marker 200,000 SNP marker

250 ng DNA

cost-effective solution

CytoScan Optima

18,018 CN marker 148,450 SNP marker

250 ng DNA

analysis of prenatal and miscarriage samples

OncoScan

220,000 SNP marker

80 ng DNA

cancer applications, FFPE samples

The OncoScan Array was developed for cancer applications. The OncoScan assay utilizes the Molecular Inversion Probe (MIP) technology, which has been optimized for highly degraded FFPE samples. It enables whole-genome copy number (CN), loss of heterozygosity (LOH), and key somatic mutations analysis and provides high-resolution copy number detection (50-100 kb copy number resolution in ~900 cancer genes, 300 kb genome-wide copy number resolution outside of the cancer genes).